Its synthesis is stimulated through growth factors through the Ras/Raf/MEK/ERK pathway, which continues to do so as long as growth factors are present.
If cyclin D is continuously expressed, an important regulator of the cell cycle is lost. This mutation can lead to conditions such as breast cancers and lymphomas.
Cyclin D is an oncogene that drives cell proliferation as well as targets Rb, a cancer supressor gene.
Cell Cycle Checkpoints
Spindle assembly checkpoints stops mitosis at metaphase if chromosomes are not properly aligned.
DNA damage checkpoints ensure that damaged DNA is not replicated and passed off to daughter cells.
No comments:
Post a Comment